FENOFIBRATE

Indications & Dose:

Adjunct to diet and other appropriate measures in mixed hyperlipidaemia if statin contra-indicated or not tolerated

Adjunct to diet and other appropriate measures in severe hypertriglyceridaemia

Adjunct to statin in mixed hyperlipidaemia if triglycerides and HDLcholesterol inadequately controlled in patients at high cardiovascular risk

• BY MOUTH USING CAPSULES

Adult: Initially 200 mg daily, then increased if necessary to 267 mg daily, maximum 200mg daily with concomitant statin, 200mg capsules not appropriate for use in renal impairment, 267mg capsules not appropriate for initial dose titration, or in renal impairment

• BY MOUTH USING TABLETS

Adult: 160 mg Adult: 160 mg daily, tablets not appropriate in renal impairment

Contraindications:

Severe renal or hepatic impairment, hypoalbuminaemia, primary billiary cirrhosis, gall bladder disease, nephortic syndrome.

Pregnancy & breast-feeding.

Side Effects:

Nausea, anorexia, gastric pain, pruritis, urticaria impotency, headache, dizziness, vertigo, fatigue hairloss myotoxicity.Alopecia, skin rash, leukopenia, myalgia.

Cautions:

Precautions:

Interaction:

Drugs

 Anti-coagulants: Increa-ses efficacy of anti-coagulants requiring dose of the latter to be reduced by half.

Sulfonyl ureas: Activity potentiated

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: