Irbesartan

Indications & Dose:

Hypertension 

• BY MOUTH

Adult 18–74 years: Initially 150 mg once daily, increased if necessary to 300 mg once daily

Adult 75 years and over: Initially 75–150 mg once daily, increased if necessary to 300 mg once daily

Hypertension in patients receiving haemodialysis

• BY MOUTH

Adult: Initially 75–150 mg once daily, increased if necessary to 300 mg once daily

Renal disease in hypertensive type 2 diabetes mellitus  

• BY MOUTH

Adult 18–74 years: Initially 150 mg once daily,increased if tolerated to 300 mg once daily Adult 75 years and over: Initially 75–150 mg once daily, increased if tolerated to 300 mg once daily

Renal disease in hypertensive type 2 diabetes mellitus in patients receiving haemodialysis

• BY MOUTH

Adult: Initially 75–150 mg once daily, increased if tolerated to 300 mg once daily 

Contraindications:

Side Effects:

CNS: Dizziness, headache, weakness or tiredness

CV: First dose hypotension, fluid retention, orthostatic effects, syncope

GI: Diarrhea, dyspepsia/heartburn

MS: Trauma

RESP: Cough, upper respiratory infection

MISC: Angioedema

Cautions:

Precautions:

Angioedema (associated with aspirin and/or penicillin allergy), aortic or mitral valve stenosis, coronary artery disease, breast feeding, elderly patients, hypertrophic cardiomyopathy, hypotension (sodium or volume depleted patients), pregnancy, renal artery stenosis, solitary kidney, or CHF 

PREGNANCY AND LACTATION:Pregnancy category C (first trimester—category D, second and third trimesters); drugs acting directly on the renin -aniotensin aldosterone system are documented to cause fetal harm (hypotension, oligohydramnios, neonatal anemia, hyperkalemia, neonatal skull hypoplasia, anuria, and renal failure; neonatal limb contractures, craniofacial deformities, and hypoplastic lung development; breast milk excretion unknown

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