PERINDOPRIL

Indications & Dose:

Adult:

CCF/ Hypertension,

initially 2 mg daily, usual maintenance dose 4-8 mg once daily, max. 8 mg daily. Note: In hypertension discontinue diuretic 3 days before hand and resume later if required. Heart Failure(adjunct), initial dose 2 mg in the morning under close medical supervision; usual maintenance 4 mg daily.

Elderly 2mg daily initially under closed supervission

• Following myocardial infraction or revascular-isation initially 4mg once daily in morning, increased after 2 weekes to 8mg once daily if tolerated

Children

Not recommended

Contraindications:

In children, pregnancy & breast-feeding.

Side Effects:

Anorexia, nausea, vomiting, skin rash, cough, proteinuria, fatigue, angioneurotic oedema, decrease in haemoglobin, sleep disturbances.

Cautions:

Old age: Use with caution.

Precautions:

Interaction:

Drugs

Nitrates, Diuretics, ß-blockers, Anti-depressants, Alcohol,Calcium channel blockers: Enhanced hypotensive effect

 Potassium sparing diuretics: Hyperkalemia. Sex hormones: Oestrogens and combined oral contraceptives antagonise hypotensive effect.

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: