PRAZOSINHCL

Indications & Dose:

 BY MOUTH Adults Congestive cardiac failure:Initially 500mcg 2-4 times daily, increasing to 4mg daily in divided doses, maintain; 4-20mg in divided doses.Hypertension:Initially 0.5mg preferably at bed time (1st dose may cause collapse due hypotension). Increase to 1mg 2-3 times daily after 3-7 days. maint. 4-20mg daily in divided doses.Raynaud’s syndrome :Initially 500mcg 2 times daily, increased in necessary after 3-4 days to usual maintainance 1-2 mg twice daily.BPH: BY MOUTH Initially 500mcg bid for 3-7 days, adjust subsequently according to response. Max. maintenance 2mg bid. Child l BY BY MOUTH • PO 0.5-7 mg tid 

Contraindications:

Compensatory hyperten-sion .

Side Effects:

CNS: Anxiety, asthenia, ataxia, depression, dizziness, fever, headache, hypertonia, insomnia,. nervousness, paresthesia, somnolence CV: Chest pain, dysrhythmia, edema, 1st-dose” syncope, flushing, palpitations, postural hypotension, tachycardia EENT: Abnormal vision, tinnitus, vertigo GI: Abdominal discomfort, constipation, diarrhea, dry mouth, flatulence, nausea, vomiting GU: Incontinence, polyuria MS: Arthralgia, myalgia RESP: Dyspnea SKIN: Pruritus, rash

Cautions:

Precautions:

Children, hepatic disease Pregnancy, breast-feeding & old age: Reduce initial dose.

Interaction:

Drugs ACE inhibitors: Exaggerated 1st-dose response to Prazosin B-adrenergic blockers: Exaggerated first-dose response to prazosin NSAIDs: Inhibits antihypertensive response to Prazosin Verapamil: Reduces first pass metabolism of Prazosin

Warnings:

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Lactations:

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Counselling:

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Patient And Carer Advice: