INDAPAMIDE

Indications & Dose:

Edema (CHF, cirrhosis, corticosteroid and estrogen therapy); hypercalciuria; hypertension, Raynaud’s disease, Essential hypertension.

• BY MOUTH

Adult 2.5mg or 1.5mg sustained release once daily in the morning. Increased to 5mg daily after 1wk, if indicated.

Children: Not recommended. 

Contraindications:

Recent cerebrovascular accident. Severe hepatic insufficiency, anuric renal failure.

Side Effects:

CNS: Vertigo, dizziness, fatigue, headache, paresthesias, weakness

CV: Dysrhythmias, orthostatic hypotension, palpitations

EENT: Blurred vision, increased intraocular pressure, loss of hearing, nasal congestion, tinnitus

GI: Abdominal pain, anorexia, constipation, cramps, diarrhea, dry mouth, hepatitis, jaundice, nausea, pancreatitis, vomiting

GU: Decreased libido, frequency, impotence, increased creatinine, BUN HEMS: Inhibits platelet aggregation

METAB: Hypercalcemia, hyperglycemia, hyperuricemia, hypochloremic alkalosis, hypokalemia, hypomagnesemia, hyponatremia

MS: Cramps

SKIN: Photosensitivity, pruritus, rash, urticaria

Cautions:

Precautions:

Fluid and electrolyte imbalance (including sodium, potassium, chloride, magnesium, calcium), renal disease, hepatic disease, gout, COPD, lupus erythematosus, diabetes mellitus, hyperparathyroidism, vomiting, diarrhea.

Pregnancy, breast-feeding & in old age: Use with caution.

Interaction:

Drugs

Angiotensin-converting enzyme inhibitors: Risk of postural hypotension when added to ongoing diuretic therapy; more common with loop diuretics; first dose hypotension possible in patients with sodium depletion or hypovolemia due to diuretics or sodium restriction: hypotensive response is usually transient; hold diuretic day of first dose

Corticosteroids: Concomitant therapy may result in excessive potassium loss

Diazoxide : Blunt insulin secretion; results in hyperglycemia

Lithium: Concurrent use may result in elevated serum levels of lithium; monitor carefully Nonsteroidal antiinflammatory drugs: Concurrent may reducediuretic and anti hypertensive effects

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: