Indications & Dose:
Raynaud’s syndrome
Angina prophylaxis (not recommended)
Postponement of premature labour
Adult: Initially 20 mg, followed by 10–20 mg 3– 4 times a day, adjusted according to uterine activity
Hiccup in palliative care
Adult: 10 mg 3 times a day
SR or CC tabs once daily.
Children: PO 0.25-0.5mg/kg/dose every 6-8 hr. SR preparations not recommended
Contraindications:
Use of immediate-release preparations in patients with severe obstructive CAD or recent MI, hypertensive emergencies
Side Effects:
CNS: Anxiety, asthenia, depression, dizziness, fatigue, headache, insomnia, malaise, nervousness, paresthesia, somnolence, tremor
CV: Bradycardia, dysrhythmia, hypotension, palpitations, peripheral edema, syncope, tachycardia
GI: Abdominal cramps, constipation, diarrhea, dry mouth, flatulence, gastric upset, nausea, vomiting
GU: Nocturia, polyuri
SKIN: Hair loss, pruritus, rash, urticaria
MISC: Cough, epistaxis, flushing, muscle cramps, nasal congestion, sexual dysfunction, shortness of breath, sweating, tinnitus, weight gain
Cautions:
Precautions:
CHF, hypotension, hepatic insufficiency, renal function impairment, aortic stenosis, elderly, children, recent β blocker withdrawal
Interaction:
Drugs
Barbiturates, rifampin, rifabutin: Reduced plasma concentrations of nifedipine
Beta-blockers: Enhanced effects of (B-blockers, hypotension; increased metoprolol and propranolol concentrations; additive negative effects on myocardial contractility
Cimetidine, ranitidine, famotidine: Increased nifedipine concentrations possible
Digitalis glycosides: Increased digitalis levels; increased risk of toxicity
Diltiazem: Increased serum concentrations of nifedipine Doxazosin: Enhanced hypotensive effects
Fentanyl: Severe hypotension or increased fluid volume requirements
Food: Increased absorption of Adalat CC
Grapefruit juice: Increased serum nifedipine concentrations
Histamine H2-antagonists: Increased blood level of nifedipine with cimetidine
Lansaprazole: Increased nifedipine absorption
Magnesium: Potential for transient hypotensive effect
Phenytoin: Increased phenytoin concentration
Quinidine: Reduced blood concentrations of quinidine
Vincristine: Marked increase in vincristine half-life, clinical significance unknown.
Warnings:
Adverse Effects:
Lactations:
Has been used for tocolysis and as an antihypertensive agent in pregnant women; compatible with breast feeding
Special Precautions:
Counselling:
Side Effects Or Adverse Reactions:
Patient And Carer Advice:
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