FELODIPINE

Indications & Dose:

Prophylaxis of angina

• BY MOUTH

Adult: Initially 5 mg once daily; increased if necessary to 10 mg once daily, to be taken in the morning

Elderly: Initially 2.5 mg once daily; increased if necessary to 10 mg once daily, to be taken in the morning

Hypertension

• BY MOUTH

Adult: Initially 5 mg once daily; usual maintenance 5–10 mg once daily, to be taken in the morning, doses above 20 mg daily rarely needed

Elderly: Initially 2.5 mg daily; usual maintenance 5–10 mg once daily, to be taken in the morning, doses above 20 mg daily rarely needed 

Contraindications:

Hypersensitivity to any ingredient of the preparation. Aortic stenosis, avoid within 1 month of myocardial infarction.Pregnancy, breast-feeding.

Side Effects:

CNS: Anxiety, depression, dizziness, fatigue, headache, insomnia, light headedness, tinnitus

CV: Edema, hypotension, Ml, palpitations, pulmonary edema, tachycardia, syncope

EENT: Cough; epistaxis, nasal congestion

GI: Gastric upset, gingival hyperplasia

GU: Nocturia, polyuria

HEME: Anemia 

RESP: Shortness of breath, wheezing SKIN: Pruritus, rash

MISC: Flushing, sexual difficulties

Cautions:

Precautions:

Hypotension (<90 mm Hg systolic), hepatic injury, children, renal disease, elderly

Interaction:

Drugs 

Barbiturates: Decreased felodipine bioBrands Available with Cost

Digitalis glycosides: Increased digitalis levels; increased risk of toxicity 

Erythromycin: Increased felodipine concentrations

Fentanyl: Severe hypotension or increased fluid volume requirements

Grapefruit juice: Inhibits felodipine metabolism; 200% increase in AUC

Histamine. H2 antagonists: Increased bioBrands Available with Cost of felodipine

Hydantoins: Serum felodipine level may be decreased

Propranolol: Enhanced hypotension, increased propranolol concentrations

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: