Indications & Dose:
Treatment of venous thromboembolism in pregnancy
Adult (body-weight up to 50 kg): 40 mg twice daily, dose based on early pregnancy body-weight
Adult (body-weight 50–69 kg): 60 mg twice daily, dose based on early pregnancy body-weight
Adult (body-weight 70–89 kg): 80 mg twice daily, dose based on early pregnancy body-weight
Adult (body-weight 90 kg and above): 100 mg twice daily,dose based on early pregnancy body-weight
Prophylaxis of deep-vein thrombosis, especially insurgical patients—moderate risk
Adult: 20 mg for 1 dose, dose to be given approximately 2 hours before surgery, then 20 mg every 24 hours
Prophylaxis of deep-vein thrombosis, especially surgicalpatients—high risk (e.g. orthopaedic surgeryl
Adult: 40 mg for 1 dose, dose to be given 12 hours before surgery, then 40 mg every 24 hours
Prophylaxis of deep-vein thrombosis in medical patients
Adult: 40 mg every 24 hours
Treatment of deep-vein thrombosis |
Treatment of pulmonary embolism
Adult: 1.5 mg/kg every 24 hours until adequate oral anticoagulation established
Treatment of acute ST-segment elevation myocardial infarction (patients not undergoing percutaneous coronary intervention)
Adult 18–74 years: Initially 30 mg, followed by (by subcutaneous injection) 1 mg/kg for 1 dose, then (by subcutaneous injection) 1 mg/kg every 12 hours (max. per dose 100 mg) for up to 8 days, maximum dose applies for the first two subcutaneous doses onl
Adult 75 years and over: 750 micrograms/kg every 12 hours (max. per dose 75 mg), maximum dos applies for the first two doses only
Treatment of acute ST-segment elevation myocardial infarction (patients undergoing percutaneous coronary intervention)
Adult 18–74 years: Initially 30 mg, followed by (by subcutaneous injection) 1 mg/kg for 1 dose, then (by subcutaneous injection) 1 mg/kg every 12 hours (max. per dose 100 mg) for up to 8 days, maximum dose applies for the first two subcutaneous doses only, then (by intravenous injection) 300 micrograms/ kg for 1 dose, dose to be given at the time of procedure if the last subcutaneous dose was given more than 8 hours previously
Adult 75 years and over: 750 micrograms/kg every 12 hours (max. per dose 75 mg), maximum dose applies for the first two doses only, then (by intravenous injection) 300 micrograms/kg for 1 dose, dose to be given at the time of procedure if the last subcutaneous dose was given more than 8 hours previously
Unstable angina
Non-ST-segment-elevation myocardial infarction
Adult: 1 mg/kg every 12 hours usually for 2–8 days (minimum 2 days)
Contraindications:
Active major bleeding; thrombocytopenia associated with positive in vitro tests for anti-platelet antibody in the presence of enoxaparin
Side Effects:
CNS: Confusion, fever
CV: Edema
GI: Increased ALT, AST; nausea
HEME: Hemorrhage, hypochromic anemia, thrombocytopenia
SKIN: Echymosis, erythema at inj site, hematoma, local irritation, pain
Cautions:
Precautions:
Bacterial endocarditis, bleeding disorder, active ulceration, angiodysplastic GI disease, hemorrhagic stroke; recent brain, spinal, or ophthalmological surgery; history of heparin-induced thrombocytopenia; renal function impairment; elderly; children; neuroaxial anesthesia
PREGNANCY ; Excretion into breast milk unknown; use caution in nursing mothers
Interaction:
Drugs
Aspirin: Increased risk of hemorrhageOral anticoagulants: Additive anticoagulant effects
Warnings:
Adverse Effects:
Lactations:
Special Precautions:
Counselling:
Side Effects Or Adverse Reactions:
Patient And Carer Advice:
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