Clinical Pharmacology Details


RIVAROXABAN


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Indications & Dose:

 Prophylaxis of venous thromboembolism following knee replacement surgery



Adult: 10 mg once daily for 2 weeks, to be started 6–10 hours after surgery


Prophylaxis of venous thromboembolism following hip replacement surgery



Adult: 10 mg once daily for 5 weeks, to be started 6–10 hours after surgery


Initial treatment of deep-vein thrombosis


Initial treatment of pulmonary embolism



Adult: Initially 15 mg twice daily for 21 days, to be taken with food


Continued treatment of deep-vein thrombosis (following initial treatment)


Continued treatment of pulmonary embolism (following initial treatment) Prophylaxis of recurrent deep-vein thrombosis ,Prophylaxis of recurrent pulmonary embolism



Adult: 20 mg once daily, to be taken with food


Prophylaxis of stroke and systemic embolism in patients with non-valvular atrial fibrillation and with at least one of the following risk factors: congestive heart failure, hypertension, previous stroke or transient ischaemic attack, age 75 years, or diabetes mellitus



Adult: 20 mg once daily, to be taken with food


Prophylaxis of atherothrombotic events following an acute coronary syndrome with elevated cardiac biomarkers (in combination with aspirin alone or aspirin and clopidogrel) l



Adult: 2.5 mg twice daily usual duration 12months

Contraindications:

Active pathological bleeding,Severe hypersensitivity reaction this molecule

Side Effects:

Cautions:

Precautions:

Interaction:


Use in specific Populations



 

Warnings:


Promptly evaluate signs and symptoms of blood loss.



 

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

The most common adverse reaction (>5%) was bleeding.

Patient And Carer Advice: