TICLOPIDINE

Indications & Dose:

Reducing the risk of thrombotic stroke in aspirin intolerant patients or aspirin failures; prevention of thrombosis following intra coronary stent placement*; intermittent claudication*; chronic arterial occlusion*; sickle cell disease

BY MOUTH

Adults 250mg twice daily with food.

Children Not recommended

Contraindications:

Current blood dyscrasia (neutropenia, thrombocytopenia); history of TTP; hemostatic disorder or active pathological bleeding (such as being peptic ulcer or intracranial bleeding); patients with severe liver impairment 

Side Effects:

GI (40% have GI effects): Cholestatic jaundice,diarrhea, Gf discomfort, hepatitis; increasedcholesterol, LDL, VLDL; nausea, vomiting

HEME: Agranulocytosis, bleeding (epistaxis,hematuria, conjunctival hemorrhage, GI bleeding),neutropenia, thrombocytopenia

SKIN: Pruritus, rash

Cautions:

Precautions:

Past liver disease, renal disease, elderly, children, increased bleeding risk (trauma, surgery, or pathological conditions, dental procedures)

Pregnancy ; use caution in nursing mothers

Interaction:

Drugs

Cyclosporine: Potential for reduction in blood cyclosporine concentrations

Phenytoin: Inhibition of hepatic metabolism of phenytoin; potential for development of phenytoin toxicity, reduction in phenytoin dose may be necessary

Theophylline: Increased theophylline level via inhibition of metabolism, increased risk of toxicity

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: