NIMODIPINE

Indications & Dose:

Prevention of ischaemic neurological defects following aneurysmal subarachnoid haemorrhage

• BY MOUTH

Adult: 60 mg every 4 hours, to be started within 4 days of aneurysmal subarachnoid haemorrhage and continued for 21 days

Treatment of ischaemic neurological defects following aneurysmal subarachnoid haemorrhage

•  BY INTRAVENOUS INFUSION

Adult (body-weight up to 70 kg): Initially up to 0.5 mg/hour, increased after 2 hours if no severe fall in blood pressure; increased to 2 mg/hour and continue for at least 5 days (max. 14 days); if surgical intervention during treatment, continue for at least 5 days after surgery; max. total duration of nimodipine use 21 days, to be given via central catheter Adult (body-weight 70 kg and above): Initially 1 mg/hour, increased after 2 hours if no severe fall in blood pressure; increased to 2 mg/ hour and continue for at least 5 days (max. 14 days); if surgical intervention during treatment, continue for at least 5 days after surgery; max. total duration of nimodipine use 21 days, to be given via central catheter

Treatment of ischaemic neurological defects following aneurysmal subarachnoid haemorrhage in patients with unstable blood pressure

•  BY INTRAVENOUS INFUSION

Adult: Initially up to 0.5 mg/hour, increased after 2 hours if no severe fall in blood pressure; increased to 2 mg/hour and continue for at least 5 days (max. 14 days); if surgical intervention during treatment, continue for at least 5 days after surgery; max. total duration of nimodipine use 21 days, to be given via central catheter

Contraindications:

Side Effects:

CNS: Dizziness, headache, mental depression

CV:  ECG  abnormalities,  edema,  flushing,hypotension, palpitations

GI: Constipation, hepatitis, jaundice, lowerabdominal discomfort

HEME: Anemia, thrombocytopenia

MS: Muscle pain

RESP: Dyspnea

 SKIN: Rash

Cautions:

Precautions:

 Impaired hepatic, renal function;children < 18 yr

Interaction:

Drugs

Cimetidine:Increasedserum nimodipineconcentrations

Omeprazole: Increased serum nimodipineconcentrations

Valproic acid: Increased oral bioBrands Available with Cost of nimodipine

Warnings:

Adverse Effects:

Lactations:

Pregnancy. Monitor B.P. Nimotop infusion is incompatible with PVC.

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: