ONDANSETRON HCL

Indications & Dose:

• BY INJECTION

Chemotherapy and radiotherapy: 

Highly emetogenic regimens: 

Adults: Single dose of 8mg by slow i.v inj immediately prior to chemotherapy; followed by either two doses of 8mg by i.v inj repeated 2-4 hours apart or by 1mg per hour by i.v infusion for up to 24 hours; or single dose of 32mg in 50-100ml saline infused over 15 minutes prior to chemotherapy.  After first 24 hrs. followed by 8mg orally twice daily for up to 5 days. Efficacy may be enhanced by addition of dexamethasone 20mg i.v prior to chemotherapy. 

Less emetogenic regimens or radiotherapy: 

Adults: 8mg by slow i.v inj immediately prior to chemotherapy, or orally 1-2 hours before, followed by 8mg orally twelve hourly. After first 24 hrs, followed by 8mg orally twice daily for up to 5 days. 

Postoperative prophylaxsis: 

Adults: 8mg orally 1 hour prior to anaesthesia followed by two doses of 8mg orally at 8 hourly intervals; or single dose of 4mg by slow i.v or i.m inj. at induction of anaesthesia. Treatment, single dose of 4mg by slow i.v or i.m inj. 

Chemotherapy   and radiotherapy

Children: only: 5mg per square meter i.v immediately prior to procedure, followed by 4mg orally 12 hours later. After first 24 hrs, followed by 4mg orally twice daily for up to 5 days.

Contraindications:

Side Effects:

CNS: Headache, lightheadedness, seizures

CV: Angina, bradycardia, syncope, tachycardia

EENT: Blurred vision

GI: Constipation, diarrhea, transient elevation in liver enzymes

METAB: Hypokalemia

RESP: Bronchospasm

SKIN: Rash

Cautions:

Precautions:

Abdominal surgery (may mask ileus or gastric distension), children 1-3 yr

Interaction:

Warnings:

Adverse Effects:

Lactations:

PREGNANCY AND LACTATION: Pregnancy category B; has been used in the treatment of hyperemesis gravidarum

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: