GRANISETRON

Indications & Dose:

Nausea and vomiting induced by cytotoxic chemotherapy or radiotherapy, 

BY MOUTH:  

Adult: 1-2mg within 1 hour before start of treatment, then 2 mg daily in 1-2 divided doses during treatment; when intravenous infusion also used, max. combined total 9mg in 24 hours; 

Child: 20 micrograms/kg (max. 1 mg) within 1 hour before start of treatment, then 20 micrograms/kg (max. 1mg) twice daily for up to 5 days during treatment.

BY INJECTION

Adult: By intravenous injection (diluted in 15mL sodium chloride 0.9% and given over not less than 30 seconds) or by intravenous infusion (over 5 minutes), prevention, 3 mg before start of cytotoxic therapy (up to 2 additional 3-mg doses may be given within 24 hours); treatment, as for prevention (the two additional doses must not be given less than 10 minutes apart); max. 9 in 24 hours

Child: by intravenous infusion, (over 5 minutes), prevention, 40 micrograms/kg (max. 3mg) before start of cytotoxic therapy; treatment, as for prevention – one additional dose of 40 micrograms/kg (max. 3 mg) may be given within 24 hours (not less than 10 minutes after initial dose).

Postoperative nausea and vomiting

BY INJECTION

Adult: by intravenous injection (diluted to 5 mL and given over 30 seconds), prevention 1 mg before induction of anaesthesia; treatment, 1mg, given as for prevention; max. 2 mg in one day; 

Child:not recommended.

Contraindications:

Side Effects:

Cautions:

Precautions:

Child <2 yr

Interaction:

Warnings:

Adverse Effects:

Lactations:

PREGNANCY AND LACTATION: Pregnancy category B; breast milk excretion unknown

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

CNS: Anxiety, headache, somnolence, weakness

CV.- Atrioventricular block, hypertension, hypotension, ventricular ectopy

EENT: Dysgeusia

GI: Constipation, diarrhea, elevated transaminase

MISC: Fever

Patient And Carer Advice: