Co-Preparation

Indications & Dose:

Specially recommended for Nausea and Vomiting in pregnancy.

DOSE: 1-2 tab three times per day.

ANTIEMETICS AND ANTINAUSEANTS › 

NEUROKININ RECEPTOR ANTAGONISTS

Aprepitant

APREPITANT

INDICATIONS AND DOSE

Adjunct to dexamethasone and a 5HT3-receptor

antagonist in preventing nausea and vomiting associated with moderately and highly emetogenic chemotherapy

BY MOUTH

Adult: Initially 125 mg, dose to be taken 1 hour before

chemotherapy, then 80 mg once daily for 2 days, consult product literature for dose of concomitant corticosteroid and 5HT3-antagonist

CONTRA-INDICATIONSAcute porphyrias p. 930

Contraindications:

Side Effects:

Common or very common Anorexia . asthenia . constipation . diarrhoea . dizziness . dyspepsia . headache . hiccups

Uncommon Abdominal pain . abnormal dreams . acne .

anaemia . anxiety . bradycardia . chills . colitis . confusion . conjunctivitis . cough . drowsiness . dry mouth . duodenal ulcer . dysuria . euphoria . flatulence . flushing . haematuria . hyperglycaemia . hyponatraemia . myalgia . neutropenia . oedema . palpitations . pharyngitis . photosensitivity . polyuria . pruritus . rash . sneezing . stomatitis . sweating .

taste disturbance . thirst . tinnitus . weight changes

Frequency not known Dysarthria . dyspnoea . insomnia . Stevens-Johnson syndrome . urticaria . visual disturbances

CONCEPTION AND CONTRACEPTION

Effectiveness of hormonal contraceptives reduced—effective nonhormonal methods of contraception necessary during treatment and for 2 months after stopping aprepitant.

PREGNANCY Avoid unless potential benefit outweighs

risk—no information available.

BREAST FEEDING Avoid—present in milk in animal studies.

HEPATIC IMPAIRMENT Caution in moderate to severe

impairment

Cautions:

Precautions:

Interaction:

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: