PROMETHAZINE THEOCLATE

Indications & Dose:

Symptomatic treatment of various allergic conditions; active and prophylactic treatment of motion sickness; preoperative, postoperative, or obstetric sedation; nausea and vomiting associated with anesthesia and surgery; adjunct to analgesic for control of postoperative pain.

BY MOUTH

Adult

Motion sickness

 25 mg at bedtime before long journeys or 1-2 hours before short jurneys.

Nausea

25 mg one to three times daily.

Children: under 5 years not recommended, 5-10 years half the adult dose.

Contraindications:

Narrowangle glaucoma

Side Effects:

CNS: Anxiety, confusion, dizziness, drowsiness, EPSreactions, paradoxical hyperexcitability (children, relative overdose), euphoria, fatigue, poor coordination

CV: Hypotension, palpitations, tachycardia

EENT: Blurred vision, dilated pupils, dry nose, nasal stuffiness, tinnitus

GI: Anorexia, cholestatic jaundice, constipation, diarrhea, dry mouth, nausea, vomiting

GU: Amenorrhea, dysuria, galactorrhea, gynecomastia, impotence, urinary retention

HEME: Agranulocytosis, hemolytic anemia, thrombocytopenia

METAB: Hyperprolactinemia 

RESP: Chest tightness, increased thick secretions, wheezing

SKIN: Photosensitivity, rash, urticaria

Cautions:

Precautions:

Acute asthma, bladder neck obstruction, prostatic hypertrophy, predisposition to urinary retention, cardiovascular disease, glaucoma, hepatic function impairment, hypertension, history of peptic ulcer, seizure disorder, intestinal obstruction

Interaction:

Drugs

CNS depressants: Additive sedative action

Labs

• False increase: Tricyclic antidepressant

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: