RABEPRAZOLE

Indications & Dose:

BY MOUTH

Adult

Zollinger -Ellison Syndrome: 

60mg one daily; max 120mg one daily

Benign gastric ulcer: 

20mg dialy in the morning for 6 weeks continue for further 6 weeks if not fully headed.

• GERD: 

PO 20 mg one dialy for 4 8 wk; maintenance: 20 mg one daily

• Duodenal ulcer:

 PO 20 mg one daily after breakfast for 4-8 wk

• Hypersecretory conditions: 

PO 60 mg qd; dose may need to be adjusted pen; doses as high as 100 mg and 60 mg bid have been used

Children more than 12 years

Short term treatment of GERD :20mg once daily for less than 8 weeks.

PREGNANCY AND LACTATION: Pregnancy category B; excretion into breast milk unknown, use caution in nursing mothers

Contraindications:

Side Effects:

CNS: Headache, delirium, twitching, insomnia, anxiety, dizziness, depression, somnolence, hypertonia, neuralgia, vertigo, seizure, abnormal dreams, decreased libido, neuropathy, paresthesia, tremor, agitation, amnesia, confusion, extrapyramidal reaction, hyperkinesia

CV: Chest pain, hypertension, myocardial infarction, syncope, angina, bundle branch block, palpitation, bradycardia,tachycardia, SVT, pulmonary embolus, thrombophlebitis, vasodilation, QT prolongation, ventricular tachycardia, ecchymosis, lymphadenopathy, peripheral edema

EENT: Cataract, amblyopia, glaucoma, dry eyes, abnormal vision, tinnitus, otitis media, corneal opacity, blurred vision, eye pain, retinal degeneration, strabismus

GI: Diarrhea, nausea, abdominal pain, vomiting. dyspepsia, flatulence, constipation, dry mouth, eructation, gastroenteritis, rectal hemorrhage, melena, anorexia, cholelithiasis, stomatitis; dysphagia, gingivitis, cholecystitis; increased appetite, colitis, esophagitis, glossitis, pancreatitis, proctitis, cholangitis, duodenitis, hepatitis, hepatic encephalopathy, fatty liver, salivary gland enlargement, increased transaminases

GU: Urinary frequency, cystitis, dysmenorrhea, dysuria, renal calculus, menorrhagia, polyuria, breast enlargement, impotence, hematuria, leukorrhea, otchitis, urinary incontinence

HEME: Agranulocytosis, hemolytic anemia, ltukopenia, pancytopenia, thrombocytopenia, anemia

METAB: Hyperammonemia, elevated TSH, hyperthyroidism, hypothyroidism, gout

MS: Myalgia, arthritis, leg cramps, bone pain, bursitis

RESP: Dyspnea, asthma, epistaxis, laryngitis, hiccup, hyperventilation, apnea, hypoventilation

SKIN: Dermatologic eruptions, photosensitivity, rash, pruritus, sweating, urticaria, alopecia, dry skin, herpes zoster, psoriasis

MISC: Coma, jaundice, rhabdomyolysis, weakness, fever, chills, malaise, thirst, weight gain, dehydration, weight loss

Cautions:

Precautions:

Severe hepatic impairment

Interaction:

Drugs

• Cyclosporine: Potential for increased cyclosporine concentrations

• Digoxin: Increased serum concentrations of digoxin possible

• Ketoconazole: Decreased bioavailability of ketoconazole

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: