HYOSCINE BUTYL BROMIDE

Indications & Dose:

Gastric and duodenal ulcer, hiccup, spastic disorders of G.I.T. and hypermotility, biliary dyskinesia, colonic motility disorder, oesophageal spasm, dumping syndrome.

• BY MOUTH

Adults: By mouth  20mg 4 times daily.

Syp:1tsf three to four times daily

• BY INJECTABLE

Adults/Children: Inj  6-12 year 10 mg 3 times daily. By i.m or i.v : (acute spasm) 20 mg. repeated after 30 minutes if necessary or 1 amp i.v (slowly).

• BY MOUTH

Children by mouth: Child 1 month -2 years 300-500mcg/kg (max; 5mg) 3-4 times daily. 2-5 years 5mg 3-4 times daily, 5-12 years 10mg 3-4 times daily, 12-18 years 10-20mg 3-4 times daily

Administration: for intravenous injection , may be diluted with glucose 5% or sodium chloride 9%; give over at least 1 minute

Contraindications:

Prostate hypertrophy with urinary retention, megacolon, G.I. mechanical stenosis, tachycardia.

Side Effects:

Anticholinergic effect. i.v. administration may lead to increased pulse rate, vision disturbances.

DRUG INTERACTIONS: Mantadine: Increase in anticholinergic side effects.

Atenolol, Digoxin: Efficacy of atenolol and digoxin enhanced.

Phenothiazines: Decreases antipsychotic activity, and increases anticholinergic activity.

TCAs: Increased anticholinergic side  effects (Dry mouth, constipation, urinary retention).

Cautions:

Elderly patient, urinary-retention, prostatic enlargement, tachycardia,  closed angle glaucoma.

Precautions:

Interaction:

Warnings:

Adverse Effects:

Lactations:

Special Precautions:

Driving or operating machinery. 

Pregnancy: Safety not established.

Breast-feeding: Use with caution.

Old age: May be used in reduced dose.

Counselling:

Side Effects Or Adverse Reactions:

Patient And Carer Advice: